Drug interactions
Chlorpropamide + Somatrogon
Severity: Moderate
Chlorpropamide and Somatrogon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Somatrogon is a long-acting growth hormone analog that can lower insulin sensitivity and raise blood glucose. Glycemic control in a patient on chlorpropamide may worsen once it is started.
What this interaction means in plain words
Chlorpropamide and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Somatrogon belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: growth hormone induces insulin resistance, opposing the glucose-lowering effect of the sulfonylurea.
What to do
Monitor blood glucose and HbA1c after starting or changing the somatrogon dose. Adjust the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Other interactions of Somatrogon
- Alogliptin-metformin + Somatrogon Moderate
- Alogliptin-pioglitazone + Somatrogon Moderate
- Alogliptin + Somatrogon Moderate
- Canagliflozin-metformin + Somatrogon Moderate
- Cyclosporin + Somatrogon Moderate
- Dapagliflozin-metformin + Somatrogon Moderate
Frequently asked questions
Can I take Chlorpropamide with Somatrogon?
MediHelp rates the interaction as moderate. Chlorpropamide and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Somatrogon is a long-acting growth hormone analog that can lower insulin sensitivity and raise blood glucose. Glycemic control in a patient on chlorpropamide may worsen once it is started.
How serious is the interaction between Chlorpropamide and Somatrogon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing the somatrogon dose. Adjust the antidiabetic regimen as needed.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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