Drug interactions
Chlorpropamide + Xipamide
Severity: Moderate
Chlorpropamide and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-like diuretics can impair glucose tolerance and may reduce the effect of sulfonylureas. Hyponatremia can also add to chlorpropamide's SIADH-like effects.
What this interaction means in plain words
Chlorpropamide and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Diuretic-induced hypokalemia and reduced insulin secretion cause hyperglycemia, and hyponatremia is additive with chlorpropamide.
What to do
Monitor blood glucose and serum sodium and potassium. Adjust antidiabetic therapy if glucose control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Xipamide?
MediHelp rates the interaction as moderate. Chlorpropamide and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide-like diuretics can impair glucose tolerance and may reduce the effect of sulfonylureas. Hyponatremia can also add to chlorpropamide's SIADH-like effects.
How serious is the interaction between Chlorpropamide and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum sodium and potassium. Adjust antidiabetic therapy if glucose control worsens.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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