Drug interactions
Chlorthalidone + Cosyntropin
Severity: Minor
Chlorthalidone and Cosyntropin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cosyntropin is used as a single diagnostic dose, so the added electrolyte loss with chlorthalidone is expected to be brief and small. A clinically meaningful interaction is unlikely.
What this interaction means in plain words
Chlorthalidone and Cosyntropin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorthalidone belongs to Cardiovascular; Cosyntropin belongs to Musculoskeletal.
Why it happens
Transient adrenal stimulation could add to thiazide-related potassium loss.
What to do
No special action needed for a single diagnostic dose; check potassium if the patient is already hypokalemic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorthalidone
Other interactions of Cosyntropin
Frequently asked questions
Can I take Chlorthalidone with Cosyntropin?
MediHelp rates the interaction as minor. Chlorthalidone and Cosyntropin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cosyntropin is used as a single diagnostic dose, so the added electrolyte loss with chlorthalidone is expected to be brief and small. A clinically meaningful interaction is unlikely.
How serious is the interaction between Chlorthalidone and Cosyntropin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No special action needed for a single diagnostic dose; check potassium if the patient is already hypokalemic.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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