Drug interactions
Chlorthalidone + Dichlorphenamide
Severity: Moderate
Chlorthalidone and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents promote renal potassium wasting, so together they can cause significant hypokalemia. Dichlorphenamide also causes metabolic acidosis, which can complicate electrolyte disturbances.
What this interaction means in plain words
Chlorthalidone and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Carbonic anhydrase inhibition and thiazide-type diuresis additively increase urinary potassium excretion.
What to do
Monitor serum potassium and bicarbonate at baseline and periodically. Supplement potassium or adjust therapy if levels fall.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorthalidone
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Chlorthalidone with Dichlorphenamide?
MediHelp rates the interaction as moderate. Chlorthalidone and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents promote renal potassium wasting, so together they can cause significant hypokalemia. Dichlorphenamide also causes metabolic acidosis, which can complicate electrolyte disturbances.
How serious is the interaction between Chlorthalidone and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate at baseline and periodically. Supplement potassium or adjust therapy if levels fall.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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