Drug interactions
Chlorthalidone + Fenoprofen
Severity: Moderate
Chlorthalidone and Fenoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can attenuate the antihypertensive and diuretic effects of thiazide-like diuretics such as chlorthalidone. In volume-depleted or older patients the combination may also increase the risk of acute kidney injury.
What this interaction means in plain words
Chlorthalidone and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Fenoprofen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis causes sodium and water retention and reduces renal perfusion.
What to do
Monitor blood pressure, edema and renal function, and ensure adequate hydration. Adjust antihypertensive therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Fenoprofen?
MediHelp rates the interaction as moderate. Chlorthalidone and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can attenuate the antihypertensive and diuretic effects of thiazide-like diuretics such as chlorthalidone. In volume-depleted or older patients the combination may also increase the risk of acute kidney injury.
How serious is the interaction between Chlorthalidone and Fenoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema and renal function, and ensure adequate hydration. Adjust antihypertensive therapy if control worsens.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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