Drug interactions
Chlorthalidone + Hydrochlorothiazide-olmesartan
Severity: Moderate
Chlorthalidone and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone duplicates the thiazide-like diuretic component, increasing risk of hypokalemia, hyponatremia, hypomagnesemia, hyperuricemia and volume depletion. Olmesartan only partly offsets potassium loss.
What this interaction means in plain words
Chlorthalidone and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Duplicate inhibition of the distal tubule sodium-chloride cotransporter causes additive diuresis and electrolyte loss.
What to do
Avoid using two thiazide-type diuretics together unless deliberately intended. If combined, monitor electrolytes, renal function and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Chlorthalidone and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone duplicates the thiazide-like diuretic component, increasing risk of hypokalemia, hyponatremia, hypomagnesemia, hyperuricemia and volume depletion. Olmesartan only partly offsets potassium loss.
How serious is the interaction between Chlorthalidone and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two thiazide-type diuretics together unless deliberately intended. If combined, monitor electrolytes, renal function and blood pressure.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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