Drug interactions
Chlorthalidone + Indacaterol inhaled
Severity: Moderate
Chlorthalidone and Indacaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indacaterol, a long-acting beta-2 agonist, can lower serum potassium, and chlorthalidone causes renal potassium wasting. The combination may cause additive hypokalemia, which can predispose to arrhythmias, especially in patients with hypoxia or heart disease.
What this interaction means in plain words
Chlorthalidone and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from beta-2 mediated intracellular potassium shift and diuretic-induced urinary potassium loss.
What to do
Monitor serum potassium periodically, especially at initiation and in patients with cardiac disease or severe COPD. Correct hypokalemia and consider magnesium status.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Indacaterol inhaled?
MediHelp rates the interaction as moderate. Chlorthalidone and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indacaterol, a long-acting beta-2 agonist, can lower serum potassium, and chlorthalidone causes renal potassium wasting. The combination may cause additive hypokalemia, which can predispose to arrhythmias, especially in patients with hypoxia or heart disease.
How serious is the interaction between Chlorthalidone and Indacaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium periodically, especially at initiation and in patients with cardiac disease or severe COPD. Correct hypokalemia and consider magnesium status.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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