Drug interactions
Chlorthalidone + Indapamide
Severity: Moderate
Chlorthalidone and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are thiazide-type diuretics, so the combination offers little added benefit and increases adverse effects. Hypokalemia, hyponatremia, hyperuricemia and volume depletion are more likely.
What this interaction means in plain words
Chlorthalidone and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Indapamide belongs to Cardiovascular.
Why it happens
Duplicate inhibition of the distal tubular Na+/Cl- cotransporter produces additive electrolyte loss.
What to do
Avoid using two thiazide-type diuretics together and choose a single agent. If both have been given, check sodium and potassium and stop one.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorthalidone
Other interactions of Indapamide
Frequently asked questions
Can I take Chlorthalidone with Indapamide?
MediHelp rates the interaction as moderate. Chlorthalidone and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are thiazide-type diuretics, so the combination offers little added benefit and increases adverse effects. Hypokalemia, hyponatremia, hyperuricemia and volume depletion are more likely.
How serious is the interaction between Chlorthalidone and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two thiazide-type diuretics together and choose a single agent. If both have been given, check sodium and potassium and stop one.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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