Drug interactions
Chlorthalidone + Meclofenamate
Severity: Moderate
Chlorthalidone and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as meclofenamate can blunt the antihypertensive and diuretic effects of chlorthalidone and increase the risk of acute kidney injury, especially with dehydration or pre-existing renal disease. Fluid retention and rising blood pressure may be seen with sustained use.
What this interaction means in plain words
Chlorthalidone and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and promotes sodium and water retention, counteracting diuretic effect.
What to do
Monitor blood pressure, renal function and electrolytes, and use the lowest effective NSAID dose for the shortest time. Consider paracetamol or another alternative where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Meclofenamate?
MediHelp rates the interaction as moderate. Chlorthalidone and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as meclofenamate can blunt the antihypertensive and diuretic effects of chlorthalidone and increase the risk of acute kidney injury, especially with dehydration or pre-existing renal disease. Fluid retention and rising blood pressure may be seen with sustained use.
How serious is the interaction between Chlorthalidone and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes, and use the lowest effective NSAID dose for the shortest time. Consider paracetamol or another alternative where possible.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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