Drug interactions
Chlorthalidone + Metaproterenol
Severity: Moderate
Chlorthalidone and Metaproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metaproterenol, a beta-2 agonist, can lower serum potassium through intracellular shift, and chlorthalidone causes renal potassium loss. The combination may cause clinically significant hypokalemia and increase arrhythmia risk, especially with high doses.
What this interaction means in plain words
Chlorthalidone and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from beta-2 mediated potassium uptake into cells and diuretic-induced renal potassium wasting.
What to do
Monitor serum potassium in patients on frequent or high-dose metaproterenol, especially with cardiac disease, and replace potassium and magnesium when low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Metaproterenol?
MediHelp rates the interaction as moderate. Chlorthalidone and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metaproterenol, a beta-2 agonist, can lower serum potassium through intracellular shift, and chlorthalidone causes renal potassium loss. The combination may cause clinically significant hypokalemia and increase arrhythmia risk, especially with high doses.
How serious is the interaction between Chlorthalidone and Metaproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients on frequent or high-dose metaproterenol, especially with cardiac disease, and replace potassium and magnesium when low.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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