Drug interactions
Chlorthalidone + Sacubitril / valsartan
Severity: Moderate
Chlorthalidone and Sacubitril / valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan reduces aldosterone-mediated potassium loss, which can offset the potassium wasting caused by chlorthalidone. Combined use is common and usually beneficial, but the combination of volume depletion and RAAS blockade can also cause hypotension and renal function decline.
What this interaction means in plain words
Chlorthalidone and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Angiotensin receptor blockade raises potassium while thiazide diuresis lowers it; additive effects on blood pressure and volume status.
What to do
Monitor blood pressure, serum potassium and creatinine after initiation and dose changes. Reduce the diuretic dose if symptomatic hypotension or volume depletion occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Sacubitril / valsartan?
MediHelp rates the interaction as moderate. Chlorthalidone and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valsartan reduces aldosterone-mediated potassium loss, which can offset the potassium wasting caused by chlorthalidone. Combined use is common and usually beneficial, but the combination of volume depletion and RAAS blockade can also cause hypotension and renal function decline.
How serious is the interaction between Chlorthalidone and Sacubitril / valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and creatinine after initiation and dose changes. Reduce the diuretic dose if symptomatic hypotension or volume depletion occurs.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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