Drug interactions
Chlorthalidone + Shark cartilage
Severity: Moderate
Chlorthalidone and Shark cartilage: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Shark cartilage supplements contain calcium and have been associated with hypercalcemia in some reports. Chlorthalidone reduces urinary calcium excretion, which could add to the risk of raised serum calcium.
What this interaction means in plain words
Chlorthalidone and Shark cartilage can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive calcium load from the supplement together with reduced renal calcium excretion from thiazide action.
What to do
Avoid the supplement where possible. If used, check serum calcium periodically and stop it if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Shark cartilage?
MediHelp rates the interaction as moderate. Chlorthalidone and Shark cartilage can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Shark cartilage supplements contain calcium and have been associated with hypercalcemia in some reports. Chlorthalidone reduces urinary calcium excretion, which could add to the risk of raised serum calcium.
How serious is the interaction between Chlorthalidone and Shark cartilage?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the supplement where possible. If used, check serum calcium periodically and stop it if hypercalcemia develops.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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