Drug interactions
Chlorthalidone + Telmisartan-amlodipine
Severity: Moderate
Chlorthalidone and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone adds to the blood pressure lowering effect of telmisartan and amlodipine and may cause volume depletion or renal impairment. Thiazide-like potassium loss is partly offset by the ARB, so potassium may stay normal or change in either direction.
What this interaction means in plain words
Chlorthalidone and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
Additive antihypertensive effect, with diuretic-driven volume depletion and opposing effects of ARB and diuretic on potassium.
What to do
Monitor blood pressure, serum potassium, sodium and creatinine after starting or changing doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Chlorthalidone and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone adds to the blood pressure lowering effect of telmisartan and amlodipine and may cause volume depletion or renal impairment. Thiazide-like potassium loss is partly offset by the ARB, so potassium may stay normal or change in either direction.
How serious is the interaction between Chlorthalidone and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium, sodium and creatinine after starting or changing doses.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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