Drug interactions
Chlorthalidone + Temocillin
Severity: Minor
Chlorthalidone and Temocillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temocillin contains a substantial sodium load and is cleared renally, and diuretic-induced hypokalemia may be worsened by penicillin-related effects. Pharmacokinetic interaction with chlorthalidone is only theoretical.
What this interaction means in plain words
Chlorthalidone and Temocillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular secretion; penicillins may also contribute to potassium loss.
What to do
Monitor serum potassium and renal function during prolonged courses. No dose change is routinely needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Temocillin?
MediHelp rates the interaction as minor. Chlorthalidone and Temocillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Temocillin contains a substantial sodium load and is cleared renally, and diuretic-induced hypokalemia may be worsened by penicillin-related effects. Pharmacokinetic interaction with chlorthalidone is only theoretical.
How serious is the interaction between Chlorthalidone and Temocillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function during prolonged courses. No dose change is routinely needed.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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