Drug interactions
Chlorthalidone + Trilostane
Severity: Moderate
Chlorthalidone and Trilostane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trilostane suppresses adrenal steroid synthesis including aldosterone, which can reduce potassium loss caused by chlorthalidone. It may also increase sodium loss and the risk of hypotension or hyperkalemia, especially with renal impairment.
What this interaction means in plain words
Chlorthalidone and Trilostane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of 3-beta-hydroxysteroid dehydrogenase reduces aldosterone synthesis, adding to the natriuresis of the thiazide-type diuretic while sparing potassium.
What to do
Monitor serum potassium, sodium and blood pressure during combined use, and avoid concurrent potassium supplements or potassium-sparing agents unless guided by levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Trilostane?
MediHelp rates the interaction as moderate. Chlorthalidone and Trilostane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trilostane suppresses adrenal steroid synthesis including aldosterone, which can reduce potassium loss caused by chlorthalidone. It may also increase sodium loss and the risk of hypotension or hyperkalemia, especially with renal impairment.
How serious is the interaction between Chlorthalidone and Trilostane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, sodium and blood pressure during combined use, and avoid concurrent potassium supplements or potassium-sparing agents unless guided by levels.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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