Drug interactions
Chlorthalidone + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Chlorthalidone and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a beta-agonist, can lower serum potassium and cause ECG changes, and this effect may be worsened by thiazide-type diuretics such as chlorthalidone. The risk is greater if the beta-agonist dose is exceeded.
What this interaction means in plain words
Chlorthalidone and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from beta-2 agonist-driven cellular potassium uptake and diuretic-induced renal potassium loss.
What to do
Monitor serum potassium, particularly in patients with cardiac disease or high beta-agonist doses. Correct hypokalemia and do not exceed the recommended inhaler dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Chlorthalidone and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol, a beta-agonist, can lower serum potassium and cause ECG changes, and this effect may be worsened by thiazide-type diuretics such as chlorthalidone. The risk is greater if the beta-agonist dose is exceeded.
How serious is the interaction between Chlorthalidone and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, particularly in patients with cardiac disease or high beta-agonist doses. Correct hypokalemia and do not exceed the recommended inhaler dose.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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