Drug interactions
Cholera vaccine + Cyclophosphamide
Severity: Moderate
Cholera vaccine and Cyclophosphamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclophosphamide suppresses immune function and may reduce the antibody response to cholera vaccine. Protection may therefore be inadequate in treated patients. The oral vaccine is a live attenuated product in some formulations, which adds a safety concern during profound immunosuppression.
What this interaction means in plain words
Cholera vaccine and Cyclophosphamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic immunosuppression reduces vaccine immune response.
What to do
Vaccinate at least 2 weeks before starting cyclophosphamide where possible. Avoid live oral vaccine during intensive immunosuppression and confirm the choice with the product labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Frequently asked questions
Can I take Cholera vaccine with Cyclophosphamide?
MediHelp rates the interaction as moderate. Cholera vaccine and Cyclophosphamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclophosphamide suppresses immune function and may reduce the antibody response to cholera vaccine. Protection may therefore be inadequate in treated patients. The oral vaccine is a live attenuated product in some formulations, which adds a safety concern during profound immunosuppression.
How serious is the interaction between Cholera vaccine and Cyclophosphamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before starting cyclophosphamide where possible. Avoid live oral vaccine during intensive immunosuppression and confirm the choice with the product labeling.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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