Drug interactions
Cholera vaccine + Cyclosporin
Severity: Moderate
Cholera vaccine and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporin may reduce the immune response to cholera vaccine and lead to inadequate protection. Oral cholera vaccine is live attenuated in some products, which raises concern about vaccine strain infection in immunosuppressed patients, though systemic risk is low as the organism is non-invasive.
What this interaction means in plain words
Cholera vaccine and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcineurin inhibition suppresses T-cell-dependent immune responses to vaccine antigens.
What to do
Vaccinate before starting cyclosporin when feasible. Review the specific product and vaccinate according to local immunocompromised-host guidance, and counsel on continued food and water precautions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cholera vaccine with Cyclosporin?
MediHelp rates the interaction as moderate. Cholera vaccine and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporin may reduce the immune response to cholera vaccine and lead to inadequate protection. Oral cholera vaccine is live attenuated in some products, which raises concern about vaccine strain infection in immunosuppressed patients, though systemic risk is low as the organism is non-invasive.
How serious is the interaction between Cholera vaccine and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting cyclosporin when feasible. Review the specific product and vaccinate according to local immunocompromised-host guidance, and counsel on continued food and water precautions.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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