Drug interactions
Cholera vaccine + Dexamethasone
Severity: Moderate
Cholera vaccine and Dexamethasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids at supraphysiologic doses suppress immune responses and may reduce antibody response to the oral cholera vaccine. Protection may therefore be inadequate.
What this interaction means in plain words
Cholera vaccine and Dexamethasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Corticosteroid-mediated immunosuppression blunts vaccine immune response.
What to do
If possible, complete vaccination before starting immunosuppressive corticosteroid doses or delay until therapy is reduced. Consider revaccination once immune competence has recovered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Frequently asked questions
Can I take Cholera vaccine with Dexamethasone?
MediHelp rates the interaction as moderate. Cholera vaccine and Dexamethasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids at supraphysiologic doses suppress immune responses and may reduce antibody response to the oral cholera vaccine. Protection may therefore be inadequate.
How serious is the interaction between Cholera vaccine and Dexamethasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If possible, complete vaccination before starting immunosuppressive corticosteroid doses or delay until therapy is reduced. Consider revaccination once immune competence has recovered.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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