Drug interactions
Dexamethasone + Rilpivirine
Severity: Contraindicated
Dexamethasone and Rilpivirine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilpivirine is a CYP3A4 substrate, and repeated dexamethasone dosing may reduce its concentrations, raising the risk of virologic failure and NNRTI resistance. Single-dose dexamethasone is not a concern.
What this interaction means in plain words
Dexamethasone and Rilpivirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dexamethasone belongs to Endocrine; Rilpivirine belongs to Anti Virals.
Why it happens
Dexamethasone induces CYP3A4, increasing rilpivirine clearance.
What to do
Do not use more than a single dose of systemic dexamethasone with rilpivirine; select an alternative corticosteroid or antiretroviral for longer courses.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
- Dexamethasone + Zoster vaccine live Contraindicated
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Dexamethasone with Rilpivirine?
MediHelp rates the interaction as contraindicated. Dexamethasone and Rilpivirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rilpivirine is a CYP3A4 substrate, and repeated dexamethasone dosing may reduce its concentrations, raising the risk of virologic failure and NNRTI resistance. Single-dose dexamethasone is not a concern.
How serious is the interaction between Dexamethasone and Rilpivirine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use more than a single dose of systemic dexamethasone with rilpivirine; select an alternative corticosteroid or antiretroviral for longer courses.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Smallpox vaccine live. The full list is on the Dexamethasone page.
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