Drug interactions
Cholera vaccine + Ofloxacin
Severity: Moderate
Cholera vaccine and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The oral cholera vaccine contains live attenuated bacteria, and systemic antibiotics active against the strain can kill it before it establishes immunity. This may leave the patient inadequately protected.
What this interaction means in plain words
Cholera vaccine and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity against the live attenuated vaccine strain reduces its replication and immune response.
What to do
Do not give the vaccine to patients who received an oral or parenteral antibiotic within the prior 14 days. Delay vaccination until the antibiotic course has been finished for that period.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Cholera vaccine with Ofloxacin?
MediHelp rates the interaction as moderate. Cholera vaccine and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The oral cholera vaccine contains live attenuated bacteria, and systemic antibiotics active against the strain can kill it before it establishes immunity. This may leave the patient inadequately protected.
How serious is the interaction between Cholera vaccine and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the vaccine to patients who received an oral or parenteral antibiotic within the prior 14 days. Delay vaccination until the antibiotic course has been finished for that period.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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