Drug interactions
Cholera vaccine + Prednisolone
Severity: Moderate
Cholera vaccine and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids at above-physiologic doses suppress immune responses and may blunt the antibody response to cholera vaccine. This can leave the patient less protected than expected.
What this interaction means in plain words
Cholera vaccine and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoid-mediated suppression of lymphocyte function reduces vaccine immunogenicity.
What to do
Where possible, vaccinate before starting prednisolone or defer until the dose is low or stopped. If given during therapy, consider reassessing immunity or revaccinating afterward.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Cholera vaccine with Prednisolone?
MediHelp rates the interaction as moderate. Cholera vaccine and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids at above-physiologic doses suppress immune responses and may blunt the antibody response to cholera vaccine. This can leave the patient less protected than expected.
How serious is the interaction between Cholera vaccine and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, vaccinate before starting prednisolone or defer until the dose is low or stopped. If given during therapy, consider reassessing immunity or revaccinating afterward.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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