Drug interactions
Cholera vaccine + Rituximab
Severity: Moderate
Cholera vaccine and Rituximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rituximab depletes B cells and markedly reduces antibody responses to vaccines. The cholera vaccine may therefore give little or no protection when given during or soon after treatment.
What this interaction means in plain words
Cholera vaccine and Rituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
B-cell depletion prevents generation of vaccine-specific antibodies.
What to do
Vaccinate at least 4 weeks before rituximab when possible. Otherwise delay vaccination until B-cell recovery, about 6 months after the last dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rituximab
Frequently asked questions
Can I take Cholera vaccine with Rituximab?
MediHelp rates the interaction as moderate. Cholera vaccine and Rituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rituximab depletes B cells and markedly reduces antibody responses to vaccines. The cholera vaccine may therefore give little or no protection when given during or soon after treatment.
How serious is the interaction between Cholera vaccine and Rituximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 4 weeks before rituximab when possible. Otherwise delay vaccination until B-cell recovery, about 6 months after the last dose.
What other medicines interact with Rituximab?
MediHelp also lists interactions of Rituximab with, for example, Adenovirus types 4 and 7 live, Baricitinib, Certolizumab pegol. The full list is on the Rituximab page.
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