Drug interactions
Cholera vaccine + Streptomycin
Severity: Moderate
Cholera vaccine and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The oral live attenuated cholera vaccine relies on viable bacteria colonizing the gut, and antibiotics active against the vaccine strain may reduce its effect. Parenteral streptomycin may therefore weaken the response.
What this interaction means in plain words
Cholera vaccine and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibiotic activity against the live attenuated vaccine strain reduces its replication and immunogenicity.
What to do
Avoid giving the live oral cholera vaccine during antibiotic therapy and delay vaccination for at least 14 days after the antibiotic course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Streptomycin
Frequently asked questions
Can I take Cholera vaccine with Streptomycin?
MediHelp rates the interaction as moderate. Cholera vaccine and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The oral live attenuated cholera vaccine relies on viable bacteria colonizing the gut, and antibiotics active against the vaccine strain may reduce its effect. Parenteral streptomycin may therefore weaken the response.
How serious is the interaction between Cholera vaccine and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving the live oral cholera vaccine during antibiotic therapy and delay vaccination for at least 14 days after the antibiotic course.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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