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Drug interactions

Cholera vaccine + Telavancin

Severity: Moderate

Cholera vaccine and Telavancin: moderate interaction.

Last updated

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Oral live attenuated cholera vaccine contains a bacterial strain that can be killed by systemic antibiotics. Telavancin may therefore reduce vaccine viability and the immune response, leaving the patient inadequately protected.

What this interaction means in plain words

Cholera vaccine and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Evidence level: Moderate

Why it happens

Antibacterial activity against the live attenuated vaccine strain reduces its colonization and immunogenicity.

What to do

Do not give the live oral cholera vaccine to patients who have taken antibiotics in the previous 14 days. Defer vaccination until after the antibiotic course is complete.

What to ask your pharmacist

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Frequently asked questions

Can I take Cholera vaccine with Telavancin?

MediHelp rates the interaction as moderate. Cholera vaccine and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral live attenuated cholera vaccine contains a bacterial strain that can be killed by systemic antibiotics. Telavancin may therefore reduce vaccine viability and the immune response, leaving the patient inadequately protected.

How serious is the interaction between Cholera vaccine and Telavancin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the live oral cholera vaccine to patients who have taken antibiotics in the previous 14 days. Defer vaccination until after the antibiotic course is complete.

What other medicines interact with Telavancin?

MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.

Full monographs, dosing and an interaction checker in the MediHelp app

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