Drug interactions
Cholera vaccine + Tobramycin
Severity: Moderate
Cholera vaccine and Tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The live oral cholera vaccine needs viable bacteria to colonize the gut. Systemic tobramycin may reduce this and blunt immunity, though gut exposure is limited.
What this interaction means in plain words
Cholera vaccine and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity against the live attenuated vaccine strain may reduce immunogenicity.
What to do
Delay vaccination until the antibiotic course is complete, following the labeled interval of about 14 days.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Frequently asked questions
Can I take Cholera vaccine with Tobramycin?
MediHelp rates the interaction as moderate. Cholera vaccine and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The live oral cholera vaccine needs viable bacteria to colonize the gut. Systemic tobramycin may reduce this and blunt immunity, though gut exposure is limited.
How serious is the interaction between Cholera vaccine and Tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Delay vaccination until the antibiotic course is complete, following the labeled interval of about 14 days.
What other medicines interact with Tobramycin?
MediHelp also lists interactions of Tobramycin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Tobramycin page.
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