Drug interactions
Cholera vaccine + Topotecan
Severity: Moderate
Cholera vaccine and Topotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytotoxic chemotherapy such as topotecan suppresses bone marrow and immune function, which may blunt the antibody response to the cholera vaccine. The patient may therefore have inadequate protection.
What this interaction means in plain words
Cholera vaccine and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Topotecan-induced myelosuppression and immunosuppression reduce the immune response to vaccination.
What to do
If possible, complete vaccination at least 2 weeks before chemotherapy or delay it until immune recovery after treatment. Do not rely on the vaccine for protection during chemotherapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporin + Topotecan Major
- Darunavir + Topotecan Major
Frequently asked questions
Can I take Cholera vaccine with Topotecan?
MediHelp rates the interaction as moderate. Cholera vaccine and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytotoxic chemotherapy such as topotecan suppresses bone marrow and immune function, which may blunt the antibody response to the cholera vaccine. The patient may therefore have inadequate protection.
How serious is the interaction between Cholera vaccine and Topotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If possible, complete vaccination at least 2 weeks before chemotherapy or delay it until immune recovery after treatment. Do not rely on the vaccine for protection during chemotherapy.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
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