Drug interactions
Amiodarone + Topotecan
Severity: Major
Amiodarone and Topotecan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits P-glycoprotein and may increase topotecan exposure, especially oral topotecan. This could worsen myelosuppression and gastrointestinal toxicity.
What this interaction means in plain words
Amiodarone and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Topotecan belongs to Oncology.
Why it happens
Amiodarone inhibits P-gp and BCRP-mediated efflux of topotecan, raising its absorption and systemic exposure.
What to do
Avoid with oral topotecan. With IV topotecan, monitor blood counts closely and reduce dose for toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
- Darunavir + Topotecan Major
Frequently asked questions
Can I take Amiodarone with Topotecan?
MediHelp rates the interaction as major. Amiodarone and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone inhibits P-glycoprotein and may increase topotecan exposure, especially oral topotecan. This could worsen myelosuppression and gastrointestinal toxicity.
How serious is the interaction between Amiodarone and Topotecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid with oral topotecan. With IV topotecan, monitor blood counts closely and reduce dose for toxicity.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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