Drug interactions
Cholic acid + Cyclosporin
Severity: Moderate
Cholic acid and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine inhibits the bile salt export pump, which can cause conjugated bile salts to accumulate in hepatocytes. This may blunt the benefit of cholic acid and cause liver injury or cholestasis.
What this interaction means in plain words
Cholic acid and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholic acid belongs to Gastrointestinal Tract; Cyclosporin belongs to Miscellaneous.
Why it happens
Cyclosporine inhibits BSEP, impairing biliary excretion of bile acids.
What to do
Avoid the combination where possible; if necessary, monitor serum transaminases and bilirubin regularly. Stop cholic acid if liver toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cholic acid and Cyclosporin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Cholic acid
Frequently asked questions
Can I take Cholic acid with Cyclosporin?
MediHelp rates the interaction as moderate. Cholic acid and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine inhibits the bile salt export pump, which can cause conjugated bile salts to accumulate in hepatocytes. This may blunt the benefit of cholic acid and cause liver injury or cholestasis.
How serious is the interaction between Cholic acid and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if necessary, monitor serum transaminases and bilirubin regularly. Stop cholic acid if liver toxicity develops.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
