Drug interactions
Cholic acid + Dipyridamole
Severity: Moderate
Cholic acid and Dipyridamole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholic acid labeling advises avoiding bile salt export pump inhibitors because they can promote accumulation of bile salts in hepatocytes. Dipyridamole has been reported to inhibit BSEP in vitro, so liver injury could be worsened.
What this interaction means in plain words
Cholic acid and Dipyridamole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholic acid belongs to Gastrointestinal Tract; Dipyridamole belongs to Cardiovascular.
Why it happens
Possible inhibition of the bile salt export pump (BSEP) reducing biliary excretion of conjugated bile acids.
What to do
Monitor serum transaminases and bilirubin if the combination is needed. Stop cholic acid or the interacting drug if liver injury develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dipyridamole
- Dipyridamole + Riociguat Contraindicated
- Adenosine + Dipyridamole Major
- Betrixaban + Dipyridamole Major
- Dabigatran + Dipyridamole Major
- Dipyridamole + Regadenoson Major
- Dipyridamole + Venetoclax Major
Other interactions of Cholic acid
Frequently asked questions
Can I take Cholic acid with Dipyridamole?
MediHelp rates the interaction as moderate. Cholic acid and Dipyridamole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholic acid labeling advises avoiding bile salt export pump inhibitors because they can promote accumulation of bile salts in hepatocytes. Dipyridamole has been reported to inhibit BSEP in vitro, so liver injury could be worsened.
How serious is the interaction between Cholic acid and Dipyridamole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum transaminases and bilirubin if the combination is needed. Stop cholic acid or the interacting drug if liver injury develops.
What other medicines interact with Dipyridamole?
MediHelp also lists interactions of Dipyridamole with, for example, Riociguat, Adenosine, Betrixaban. The full list is on the Dipyridamole page.
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