Drug interactions
Cholic acid + Glyburide
Severity: Major
Cholic acid and Glyburide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glyburide inhibits the bile salt export pump and may impair biliary excretion of bile acids. In patients taking cholic acid, this may promote hepatic accumulation of bile salts and liver injury.
What this interaction means in plain words
Cholic acid and Glyburide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cholic acid belongs to Gastrointestinal Tract; Glyburide belongs to Endocrine.
Why it happens
Inhibition of the hepatic bile salt export pump (BSEP) by glyburide reduces bile acid efflux.
What to do
Avoid the combination if possible and choose another antidiabetic agent. If it is necessary, monitor serum transaminases and bilirubin regularly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
- Glyburide + Miconazole Major
Other interactions of Cholic acid
Frequently asked questions
Can I take Cholic acid with Glyburide?
MediHelp rates the interaction as major. Cholic acid and Glyburide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Glyburide inhibits the bile salt export pump and may impair biliary excretion of bile acids. In patients taking cholic acid, this may promote hepatic accumulation of bile salts and liver injury.
How serious is the interaction between Cholic acid and Glyburide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and choose another antidiabetic agent. If it is necessary, monitor serum transaminases and bilirubin regularly.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Ciprofloxacin, Clarithromycin. The full list is on the Glyburide page.
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