Drug interactions
Glyburide + Insulin degludec-liraglutide
Severity: Major
Glyburide and Insulin degludec-liraglutide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a GLP-1 agonist and insulin with glyburide increases the risk of hypoglycemia, which can be severe and prolonged. Glyburide has a long duration of action and active metabolites.
What this interaction means in plain words
Glyburide and Insulin degludec-liraglutide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glyburide belongs to Endocrine; Insulin degludec-liraglutide belongs to Endocrine.
Why it happens
Additive stimulation of insulin secretion and insulin effect, producing synergistic glucose lowering.
What to do
Consider reducing the glyburide dose, or choosing a shorter-acting alternative, when this combination is started. Monitor glucose closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glyburide and Insulin degludec-liraglutide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Insulin degludec-liraglutide
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Miconazole Major
Frequently asked questions
Can I take Glyburide with Insulin degludec-liraglutide?
MediHelp rates the interaction as major. Glyburide and Insulin degludec-liraglutide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a GLP-1 agonist and insulin with glyburide increases the risk of hypoglycemia, which can be severe and prolonged. Glyburide has a long duration of action and active metabolites.
How serious is the interaction between Glyburide and Insulin degludec-liraglutide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glyburide dose, or choosing a shorter-acting alternative, when this combination is started. Monitor glucose closely.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
