Drug interactions
Cholic acid + Metformin-repaglinide
Severity: Moderate
Cholic acid and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repaglinide may inhibit the bile salt export pump, which can promote accumulation of bile salts in hepatocytes. This could increase the risk of liver injury in patients taking cholic acid.
What this interaction means in plain words
Cholic acid and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholic acid belongs to Gastrointestinal Tract; Metformin-repaglinide belongs to Endocrine.
Why it happens
Inhibition of bile salt efflux pump (BSEP) reduces biliary elimination of conjugated bile salts.
What to do
Avoid the combination where possible; if it is necessary, monitor serum transaminases and bilirubin regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Cholic acid
Frequently asked questions
Can I take Cholic acid with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Cholic acid and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Repaglinide may inhibit the bile salt export pump, which can promote accumulation of bile salts in hepatocytes. This could increase the risk of liver injury in patients taking cholic acid.
How serious is the interaction between Cholic acid and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if it is necessary, monitor serum transaminases and bilirubin regularly.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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