Drug interactions
Cholic acid + Repaglinide
Severity: Moderate
Cholic acid and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repaglinide may inhibit the bile salt export pump, and cholic acid labeling warns against BSEP inhibitors. Impaired bile salt efflux can cause accumulation of conjugated bile salts and liver injury.
What this interaction means in plain words
Cholic acid and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholic acid belongs to Gastrointestinal Tract; Repaglinide belongs to Endocrine.
Why it happens
Inhibition of the bile salt export pump (BSEP) reduces hepatic elimination of bile salts.
What to do
Avoid the combination where possible; otherwise monitor serum transaminases and bilirubin and stop if liver injury develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Other interactions of Cholic acid
Frequently asked questions
Can I take Cholic acid with Repaglinide?
MediHelp rates the interaction as moderate. Cholic acid and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Repaglinide may inhibit the bile salt export pump, and cholic acid labeling warns against BSEP inhibitors. Impaired bile salt efflux can cause accumulation of conjugated bile salts and liver injury.
How serious is the interaction between Cholic acid and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; otherwise monitor serum transaminases and bilirubin and stop if liver injury develops.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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