Drug interactions
Cholic acid + Spironolactone
Severity: Moderate
Cholic acid and Spironolactone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Spironolactone may inhibit the bile salt export pump, which could promote accumulation of bile acids in hepatocytes when given with cholic acid. This could contribute to liver injury in patients being treated for bile acid synthesis disorders.
What this interaction means in plain words
Cholic acid and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholic acid belongs to Gastrointestinal Tract; Spironolactone belongs to Cardiovascular.
Why it happens
Possible inhibition of the hepatic bile salt export pump (BSEP) reduces bile acid efflux.
What to do
Avoid combining if possible; otherwise monitor serum transaminases and bilirubin and stop cholic acid if liver injury develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Other interactions of Cholic acid
Frequently asked questions
Can I take Cholic acid with Spironolactone?
MediHelp rates the interaction as moderate. Cholic acid and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Spironolactone may inhibit the bile salt export pump, which could promote accumulation of bile acids in hepatocytes when given with cholic acid. This could contribute to liver injury in patients being treated for bile acid synthesis disorders.
How serious is the interaction between Cholic acid and Spironolactone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining if possible; otherwise monitor serum transaminases and bilirubin and stop cholic acid if liver injury develops.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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