Drug interactions
Choline magnesium trisalicylate + Dabigatran etexilate
Severity: Moderate
Choline magnesium trisalicylate and Dabigatran etexilate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates have weaker antiplatelet effects than aspirin but can still cause gastrointestinal injury, and they may increase bleeding risk with dabigatran. The effect is generally smaller than with aspirin.
What this interaction means in plain words
Choline magnesium trisalicylate and Dabigatran etexilate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive bleeding tendency from salicylate effects on mucosa and platelets with direct thrombin inhibition.
What to do
Use the lowest effective salicylate dose and monitor for gastrointestinal bleeding. Consider paracetamol as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Dabigatran etexilate?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Dabigatran etexilate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-acetylated salicylates have weaker antiplatelet effects than aspirin but can still cause gastrointestinal injury, and they may increase bleeding risk with dabigatran. The effect is generally smaller than with aspirin.
How serious is the interaction between Choline magnesium trisalicylate and Dabigatran etexilate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective salicylate dose and monitor for gastrointestinal bleeding. Consider paracetamol as an alternative.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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