Drug interactions
Choline magnesium trisalicylate + Deflazacort
Severity: Moderate
Choline magnesium trisalicylate and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates combined with corticosteroids increase the risk of gastrointestinal ulceration and bleeding. Corticosteroids may also increase salicylate clearance, so salicylate levels can rise when the steroid is stopped.
What this interaction means in plain words
Choline magnesium trisalicylate and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastrointestinal mucosal injury from prostaglandin inhibition, plus corticosteroid-induced increase in salicylate clearance.
What to do
Use the lowest effective doses, consider gastroprotection with a proton pump inhibitor, and monitor salicylate levels if the steroid dose is changed or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Choline magnesium trisalicylate with Deflazacort?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates combined with corticosteroids increase the risk of gastrointestinal ulceration and bleeding. Corticosteroids may also increase salicylate clearance, so salicylate levels can rise when the steroid is stopped.
How serious is the interaction between Choline magnesium trisalicylate and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses, consider gastroprotection with a proton pump inhibitor, and monitor salicylate levels if the steroid dose is changed or stopped.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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