Drug interactions
Choline magnesium trisalicylate + Dexamethasone
Severity: Moderate
Choline magnesium trisalicylate and Dexamethasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both corticosteroids and salicylates damage gastric mucosa, so together they increase the risk of gastrointestinal ulceration and bleeding. Corticosteroids may also lower salicylate levels, and salicylate levels can rise when the steroid is withdrawn.
What this interaction means in plain words
Choline magnesium trisalicylate and Dexamethasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastrointestinal mucosal toxicity, with corticosteroid enhancement of salicylate clearance.
What to do
Use the lowest effective doses, add gastroprotection with a proton pump inhibitor in at-risk patients, and monitor for GI bleeding and salicylate levels when dexamethasone is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Choline magnesium trisalicylate and Dexamethasone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Frequently asked questions
Can I take Choline magnesium trisalicylate with Dexamethasone?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Dexamethasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both corticosteroids and salicylates damage gastric mucosa, so together they increase the risk of gastrointestinal ulceration and bleeding. Corticosteroids may also lower salicylate levels, and salicylate levels can rise when the steroid is withdrawn.
How serious is the interaction between Choline magnesium trisalicylate and Dexamethasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses, add gastroprotection with a proton pump inhibitor in at-risk patients, and monitor for GI bleeding and salicylate levels when dexamethasone is stopped.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
