Drug interactions
Choline magnesium trisalicylate + Eprosartan-hydrochlorothiazide
Severity: Moderate
Choline magnesium trisalicylate and Eprosartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Choline magnesium trisalicylate has a weaker effect on renal prostaglandins than many NSAIDs, but at anti-inflammatory doses it may still reduce antihypertensive efficacy and affect renal function when combined with an ARB and diuretic. Risk is higher in older or volume-depleted patients.
What this interaction means in plain words
Choline magnesium trisalicylate and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate-mediated inhibition of renal prostaglandins can reduce renal perfusion and cause sodium retention, opposing ARB and thiazide effects.
What to do
Monitor blood pressure, creatinine and potassium when used regularly at higher doses. Ensure adequate hydration and use the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Eprosartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Choline magnesium trisalicylate has a weaker effect on renal prostaglandins than many NSAIDs, but at anti-inflammatory doses it may still reduce antihypertensive efficacy and affect renal function when combined with an ARB and diuretic. Risk is higher in older or volume-depleted patients.
How serious is the interaction between Choline magnesium trisalicylate and Eprosartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium when used regularly at higher doses. Ensure adequate hydration and use the lowest effective dose.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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