Drug interactions
Choline magnesium trisalicylate + Eprosartan
Severity: Moderate
Choline magnesium trisalicylate and Eprosartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Choline magnesium trisalicylate, a non-acetylated salicylate, may reduce eprosartan's antihypertensive effect and impair renal function, especially in elderly or volume-depleted patients. Its renal prostaglandin effect is generally weaker than with other NSAIDs.
What this interaction means in plain words
Choline magnesium trisalicylate and Eprosartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Reduction of renal prostaglandin synthesis lowers renal perfusion and sodium excretion, opposing angiotensin receptor blockade.
What to do
Monitor blood pressure, creatinine and potassium with regular use, and ensure adequate hydration. Switch to paracetamol if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Eprosartan?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Eprosartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Choline magnesium trisalicylate, a non-acetylated salicylate, may reduce eprosartan's antihypertensive effect and impair renal function, especially in elderly or volume-depleted patients. Its renal prostaglandin effect is generally weaker than with other NSAIDs.
How serious is the interaction between Choline magnesium trisalicylate and Eprosartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium with regular use, and ensure adequate hydration. Switch to paracetamol if renal function declines.
What other medicines interact with Eprosartan?
MediHelp also lists interactions of Eprosartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Eprosartan page.
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