Drug interactions
Choline magnesium trisalicylate + Flurbiprofen
Severity: Major
Choline magnesium trisalicylate and Flurbiprofen: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining flurbiprofen with a salicylate increases the risk of gastrointestinal irritation, bleeding and renal effects without added benefit. Salicylate may also lower flurbiprofen levels.
What this interaction means in plain words
Choline magnesium trisalicylate and Flurbiprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Duplicate COX inhibition produces additive GI mucosal injury, platelet inhibition and renal prostaglandin suppression.
What to do
Avoid using two NSAID-type agents together; choose a single agent at the lowest effective dose. Monitor for GI bleeding and renal function if combination cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Choline magnesium trisalicylate and Flurbiprofen, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Flurbiprofen?
MediHelp rates the interaction as major. Choline magnesium trisalicylate and Flurbiprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining flurbiprofen with a salicylate increases the risk of gastrointestinal irritation, bleeding and renal effects without added benefit. Salicylate may also lower flurbiprofen levels.
How serious is the interaction between Choline magnesium trisalicylate and Flurbiprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two NSAID-type agents together; choose a single agent at the lowest effective dose. Monitor for GI bleeding and renal function if combination cannot be avoided.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
