Drug interactions
Choline magnesium trisalicylate + Gliclazide
Severity: Moderate
Choline magnesium trisalicylate and Gliclazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose salicylates such as choline magnesium trisalicylate can enhance the glucose-lowering effect of gliclazide and lead to hypoglycemia. The risk is greater in older adults and those with renal impairment.
What this interaction means in plain words
Choline magnesium trisalicylate and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylates have intrinsic hypoglycemic effects and may displace sulfonylureas from protein binding, producing additive effects.
What to do
Monitor blood glucose when salicylate therapy is started, changed or stopped and reduce the gliclazide dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Choline magnesium trisalicylate and Gliclazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Gliclazide
Frequently asked questions
Can I take Choline magnesium trisalicylate with Gliclazide?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. High-dose salicylates such as choline magnesium trisalicylate can enhance the glucose-lowering effect of gliclazide and lead to hypoglycemia. The risk is greater in older adults and those with renal impairment.
How serious is the interaction between Choline magnesium trisalicylate and Gliclazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when salicylate therapy is started, changed or stopped and reduce the gliclazide dose as needed.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
