Drug interactions
Choline magnesium trisalicylate + Hydrochlorothiazide-telmisartan
Severity: Moderate
Choline magnesium trisalicylate and Hydrochlorothiazide-telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates at anti-inflammatory doses can blunt the antihypertensive effect of telmisartan and thiazides. In volume-depleted or elderly patients the combination of an NSAID, a diuretic and an ARB raises the risk of acute kidney injury. Hyperkalemia may also occur.
What this interaction means in plain words
Choline magnesium trisalicylate and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of vasodilatory renal prostaglandins reduces renal perfusion and sodium excretion, opposing the diuretic and ARB effects and impairing glomerular filtration.
What to do
Maintain hydration and monitor blood pressure, serum creatinine and potassium, especially at the start of therapy. Use the lowest effective salicylate dose or choose an alternative analgesic such as paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Hydrochlorothiazide-telmisartan?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates at anti-inflammatory doses can blunt the antihypertensive effect of telmisartan and thiazides. In volume-depleted or elderly patients the combination of an NSAID, a diuretic and an ARB raises the risk of acute kidney injury. Hyperkalemia may also occur.
How serious is the interaction between Choline magnesium trisalicylate and Hydrochlorothiazide-telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Maintain hydration and monitor blood pressure, serum creatinine and potassium, especially at the start of therapy. Use the lowest effective salicylate dose or choose an alternative analgesic such as paracetamol.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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