Drug interactions
Choline magnesium trisalicylate + Hydrochlorothiazide-valsartan
Severity: Moderate
Choline magnesium trisalicylate and Hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At anti-inflammatory doses, this salicylate can blunt the blood pressure-lowering effect of valsartan and hydrochlorothiazide and increase the risk of renal function deterioration, especially in elderly or volume-depleted patients. Non-acetylated salicylates have less prostaglandin effect than other NSAIDs, but caution remains reasonable.
What this interaction means in plain words
Choline magnesium trisalicylate and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Reduced renal prostaglandin synthesis impairs renal perfusion and sodium excretion under ARB and diuretic therapy.
What to do
Monitor blood pressure, serum creatinine and potassium, and keep patients well hydrated. Use the lowest effective salicylate dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At anti-inflammatory doses, this salicylate can blunt the blood pressure-lowering effect of valsartan and hydrochlorothiazide and increase the risk of renal function deterioration, especially in elderly or volume-depleted patients. Non-acetylated salicylates have less prostaglandin effect than other NSAIDs, but caution remains reasonable.
How serious is the interaction between Choline magnesium trisalicylate and Hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, and keep patients well hydrated. Use the lowest effective salicylate dose.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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