Drug interactions
Choline magnesium trisalicylate + Ibuprofen
Severity: Major
Choline magnesium trisalicylate and Ibuprofen: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two NSAIDs adds gastrointestinal, bleeding and renal risk without meaningful additional analgesic benefit. Ibuprofen may also interfere with the antiplatelet effect of aspirin, though this is less relevant for non-acetylated salicylates.
What this interaction means in plain words
Choline magnesium trisalicylate and Ibuprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Both drugs inhibit cyclooxygenase, producing additive gastrointestinal mucosal injury, platelet inhibition and renal prostaglandin suppression.
What to do
Avoid using two NSAIDs together and choose a single agent. If a combination is unavoidable, monitor for gastrointestinal bleeding and renal function and consider gastroprotection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Ibuprofen?
MediHelp rates the interaction as major. Choline magnesium trisalicylate and Ibuprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two NSAIDs adds gastrointestinal, bleeding and renal risk without meaningful additional analgesic benefit. Ibuprofen may also interfere with the antiplatelet effect of aspirin, though this is less relevant for non-acetylated salicylates.
How serious is the interaction between Choline magnesium trisalicylate and Ibuprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two NSAIDs together and choose a single agent. If a combination is unavoidable, monitor for gastrointestinal bleeding and renal function and consider gastroprotection.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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