Drug interactions
Choline magnesium trisalicylate + Lisinopril
Severity: Moderate
Choline magnesium trisalicylate and Lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At anti-inflammatory doses, salicylates may reduce the blood pressure lowering effect of lisinopril and contribute to renal function decline. This salicylate has weaker prostaglandin inhibition than other NSAIDs, so the effect is likely smaller.
What this interaction means in plain words
Choline magnesium trisalicylate and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Reduced renal prostaglandin synthesis opposes ACE inhibitor effects and lowers renal perfusion.
What to do
Monitor blood pressure and serum creatinine when starting or changing doses. Avoid in patients with renal impairment or volume depletion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Lisinopril?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At anti-inflammatory doses, salicylates may reduce the blood pressure lowering effect of lisinopril and contribute to renal function decline. This salicylate has weaker prostaglandin inhibition than other NSAIDs, so the effect is likely smaller.
How serious is the interaction between Choline magnesium trisalicylate and Lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum creatinine when starting or changing doses. Avoid in patients with renal impairment or volume depletion.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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