Drug interactions
Choline magnesium trisalicylate + Measles mumps and rubella vaccine
Severity: Major
Choline magnesium trisalicylate and Measles mumps and rubella vaccine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylate use after varicella-containing vaccines has been associated with Reye syndrome. Choline magnesium trisalicylate delivers systemic salicylate, so the labeled advice to avoid salicylates for six weeks after vaccination applies.
What this interaction means in plain words
Choline magnesium trisalicylate and Measles mumps and rubella vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Salicylate exposure during vaccine-strain varicella infection is associated with Reye syndrome; mechanism not fully established.
What to do
Avoid salicylates for 6 weeks after varicella-containing vaccine; use paracetamol or another non-salicylate analgesic.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Frequently asked questions
Can I take Choline magnesium trisalicylate with Measles mumps and rubella vaccine?
MediHelp rates the interaction as major. Choline magnesium trisalicylate and Measles mumps and rubella vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Salicylate use after varicella-containing vaccines has been associated with Reye syndrome. Choline magnesium trisalicylate delivers systemic salicylate, so the labeled advice to avoid salicylates for six weeks after vaccination applies.
How serious is the interaction between Choline magnesium trisalicylate and Measles mumps and rubella vaccine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid salicylates for 6 weeks after varicella-containing vaccine; use paracetamol or another non-salicylate analgesic.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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