Drug interactions
Choline magnesium trisalicylate + Meclofenamic acid
Severity: Moderate
Choline magnesium trisalicylate and Meclofenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an NSAID with a salicylate increases the risk of gastrointestinal irritation and bleeding without added benefit, and may raise the risk of renal toxicity.
What this interaction means in plain words
Choline magnesium trisalicylate and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive COX inhibition reduces gastric mucosal protection and platelet function.
What to do
Avoid using both together; select one agent. If combined, monitor for GI bleeding and renal function and consider gastroprotection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Meclofenamic acid?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an NSAID with a salicylate increases the risk of gastrointestinal irritation and bleeding without added benefit, and may raise the risk of renal toxicity.
How serious is the interaction between Choline magnesium trisalicylate and Meclofenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using both together; select one agent. If combined, monitor for GI bleeding and renal function and consider gastroprotection.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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