Drug interactions
Choline magnesium trisalicylate + Naproxen
Severity: Major
Choline magnesium trisalicylate and Naproxen: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining naproxen with a salicylate increases the risk of gastrointestinal ulceration and bleeding without added benefit. Salicylates may also modestly alter naproxen exposure and add to renal toxicity.
What this interaction means in plain words
Choline magnesium trisalicylate and Naproxen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive inhibition of cyclooxygenase and platelet function, with possible displacement of naproxen from protein binding.
What to do
Avoid concurrent use of two NSAIDs or salicylates at anti-inflammatory doses. If unavoidable, use gastroprotection and monitor for bleeding and renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Naproxen?
MediHelp rates the interaction as major. Choline magnesium trisalicylate and Naproxen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining naproxen with a salicylate increases the risk of gastrointestinal ulceration and bleeding without added benefit. Salicylates may also modestly alter naproxen exposure and add to renal toxicity.
How serious is the interaction between Choline magnesium trisalicylate and Naproxen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two NSAIDs or salicylates at anti-inflammatory doses. If unavoidable, use gastroprotection and monitor for bleeding and renal function.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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