Drug interactions
Choline magnesium trisalicylate + Ofloxacin
Severity: Moderate
Choline magnesium trisalicylate and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates may add to the CNS excitatory and seizure-provoking effect of fluoroquinolones. In addition, magnesium in this product can chelate oral ofloxacin and reduce its absorption.
What this interaction means in plain words
Choline magnesium trisalicylate and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible GABA-A antagonism enhancement, plus chelation of ofloxacin by magnesium in the gut.
What to do
Take ofloxacin at least 2 hours before the magnesium-containing salicylate. Avoid in patients with seizure history.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Choline magnesium trisalicylate and Ofloxacin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Ofloxacin?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates may add to the CNS excitatory and seizure-provoking effect of fluoroquinolones. In addition, magnesium in this product can chelate oral ofloxacin and reduce its absorption.
How serious is the interaction between Choline magnesium trisalicylate and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take ofloxacin at least 2 hours before the magnesium-containing salicylate. Avoid in patients with seizure history.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
